WhisPurr™

Welcome to WhisPurr™, THE source for drug dose modification recommendations for cats with the MDR1 mutation

NOTE: WhisPurr™ offers clinical pharmacology consulting on an individual patient/scenario basis taking into account patient factors:
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CLASS 1: Normal, active, healthy patient with no underlying disease.
CLASS 2: Mild systemic disease. Neonate or geriatric.
CLASS 3: Moderate systemic disease such as anemia, moderate dehydration, fever, or cardiac disease.
CLASS 4: Severe, systemic, life-threatening disease such as severe dehydration, shock, uremia, toxemia,
high fever, uncompensated cardiovascular disease, uncompensated diabetes, pulmonary disease, emaciation.
CLASS 5: Patients with poor short term prognosis due to advanced heart, kidney, liver and/or endocrine disease; profound shock, severe trauma, pulmonary embolus, terminal malignancy.
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Using the dropdown menu, select the medication(s) that you are intending to administer to your pet and would like to know if dosing adjustments are recommended based on the MDR1 genotype. Please note that there is no data available for dosing herbal products or ‘nutraceuticals’ in cats with the MDR1 mutation, therefore these products are not included in the dropdown menu.


Dose recommendations for drugs affected by the MDR1 mutation may also be affected by other medications your pet is being treated with. Please use the dropdown menu to select the medication(s) your pet is currently being treated with. Please note that there is no data available for assessing potential drug interactions of herbal products or ‘nutraceuticals’ in cats with the MDR1 mutation, therefore these products are not included in the dropdown menu.